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pentobarbital will lessen the extent or result of buprenorphine, long-acting injection by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Patients who transfer to buprenorphine long-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers need to be monitored to make certain